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Human growth hormone (HGH) fuels the growth of our bodies during childhood and adolescence. Released from the pituitary gland when we sleep, the hormone has the chief function of lengthening bones and increasing the thickness of soft tissues such as skin. People who don’t make enough HGH while they’re young — often because of genetic diseases or kidney failure — can be extremely short as adults. Scientists discovered a way to mass produce HGH in the 1980’s.
The ready availability of HGH — and the fact that it can’t be detected by most drug tests — has also fueled a thriving black market. Athletes inject the hormone to boost strength and muscle mass, and modern-day Ponce de Leons seek in it a way to restore their youth. Americans receive injections of HGH at longevity "spas" outside of the United States, and pay as much as $4,000 for a three-month supply. Recognizing the potential for abuse of the drug, Congress amended the Food Drug and Cosmetic Act to ban the distribution of HGH except for three specific conditions: AIDS wasting syndrome, short bowel syndrome, and growth hormone deficiency (GHD). It is not approved for athletic training or as a youth restorer.
Does human growth hormone work?
Shots of HGH undoubtedly help some children who lack the hormone, but its value for healthy adults is dubious. A 1993 study, conducted by the University of Vienna, found that a 6-week course of HGH, administered to 22 serious athletes, had no effect on body weight, body fat, or the strength of the biceps or quadriceps. The researchers concluded that while HGH may help people who lack the hormone, it apparently doesn’t change the strength or body composition of highly trained athletes.
The use of the hormone as a youth restorer is controversial. One study of healthy men between the ages of 61 and 81, published in the New England Journal of Medicine in 1990, found that HGH injections increased muscle mass, decreased body fat, and thickened the skin, but other studies have shown no real benefits.
A 2007 Stanford review of clinical studies found that use of HGH may lead to small decreases in fat mass and increases in lean body mass, but that this potential benefit is far outweighed by its risks.

What are the dangers associated with human growth hormone?
There are few studies on the long-term — or even short-term — side effects of taking human growth hormone for non-medical reasons. But there’s reason to suspect trouble. People who naturally produce too much of the hormone or have received medical treatment for growth failure often develop abnormal hearts, bones, and nerves, and are particularly likely to suffer from osteoporosis, heart failure, and other diseases. Sports medicine researchers at the University of Massachusetts, among other experts, suspect that long-term use of supplemental HGH could have similar consequences.
Studies of HGH have found side effects can include joint pain, carpal tunnel syndrome, soft tissue swelling, enlarged breasts in men, and an increased risk of diabetes. Animal studies also demonstrate an association between HGH and colon and breast cancers.
Be especially wary of over-the-counter supplements that claim to either contain HGH or enhance the body’s production of the hormone. ConsumerLab.com, a commercial testing company, reviewed the ingredients in about a dozen such products and found that none contained enough amino acids or HGH to have any effect. The company also points out that because HGH is a complex molecule that breaks down quickly, over-the-counter pills and sprays wouldn’t deliver the ingredients to your system fast enough anyway.